Final answer:
No, Dutch students at Leiden did not make tobacco popular in the 1590s.
Step-by-step explanation:
In the 1590s, Dutch students at Leiden did not make tobacco popular. Tobacco was actually a New World crop, first discovered in 1492, and its usage gradually spread across Europe starting in the late 1500s. By the 1590s, tobacco had already taken Europe by storm and had become a popular habit.