Final answer:
The best antonym for 'Parody' is 'serious, original work', as it refers to content that is authentic and sincere, as opposed to parody which involves imitation for comic effect.
Step-by-step explanation:
The best antonym for 'Parody' out of the given options is D) serious, original work. A parody is a humorous or satirical imitation of a serious piece of literature or writing. It often exaggerates or distorts the original work's characteristics to create a comic effect.
On the contrary, a 'serious, original work' is created with a sincere effort, without the intention to mock or mimic, and it is designed as an authentic piece. Hence, 'serious, original work' serves as the direct opposite in nature to a parody.