Final answer:
Activation of initiator-caspase occurs by aggregation of the procaspases with the help of adaptor proteins, resulting in the formation of active caspase.
Step-by-step explanation:
The subject of this question is Biology. Activation of initiator-caspase occurs by aggregation of the procaspases with the help of adaptor proteins. Aggregated initiator-procaspase cleave each other resulting in the formation of active caspase. This process is part of the apoptotic pathway, which is a programmed cell death process in biological systems.