Final answer:
Descartes' methodological point of departure was to combine deductive reasoning with empiricism, using sensory experiences and observations to establish the foundations of the scientific method.
Step-by-step explanation:
Descartes' methodological point of departure was to combine deductive reasoning with empiricism in order to establish the foundations of the scientific method. He believed that knowledge could be gained through sensory experiences and observations, and used deductive reasoning to form conclusions based on collected evidence. Descartes also held a dualistic view of reality, distinguishing between the physical and non-physical aspects of existence.