Final answer:
When both drugs are highly protein-bound, it can result in slower distribution to tissues, reduced clearance, and potential interactions between the drugs.
Step-by-step explanation:
When both drugs are highly protein-bound, it means that a significant portion of the drugs in the bloodstream are bound to plasma proteins. This binding can result in several effects:
- The bound drugs may have a slower distribution to the tissues, meaning they may take longer to reach their target sites in the body.
- The clearance of the drugs may be reduced, as the bound drugs are less likely to be eliminated from the body.
- There may be interactions between the two drugs, as they compete for the same binding sites on the plasma proteins. This can alter the availability and effectiveness of one or both drugs.