Question

Javier is a 45 year old surgical technologist who has been referred to the dental hygiene clinic for "deep cleaning" by his general dentist. He has type 2 diabetes mellitus, but due to his poor glycemic control, recently he has had to add insulin to his drug regimen. His medications include neutral protamine Hagedorn insulin, repaglinide (Prandin), colesevelam (WelChol), simvastatin (Zocor), lisinopril (Prinivil), and a baby aspirin. His blood pressure is 150/94, heart rate is 98, and his respirations are 15 breaths per minute. When you ask him how well his diabetes is controlled, he looks embarrasses and mumbles, "Okay, I guess." When you ask about his A1C, he says it was 8 the last time he visited the doctor. You do a finger stick test, and his results are 250. You asked him when his last visit was to the doctor, and he states that he hasn't been in several months due to a heavy work schedule of surgeries. You ask him if he has eaten because it is late in the day, and you know that he just came from the hospital. He says he has eaten and has take his medications. As you examine his oral cavity, you note that his gingiva is fiery red and erythematous, and he has several areas that appear to be periodontal abscesses. His probe readings range from 4-8mm, and there is spontaneous, excessive bleeding upon probing. The lower anterior mandibular teeth have grade 2 mobility.

Which class of oral antihyperglycemic drugs is repaglinide (Prandin)?
A. Insulin
B. Sulfonylurea
C. Meglitinides
D. Thiazolidinedione
E. Dipeptidyl-peptidase-4-inhibitor
F. a-Glucosidase inhibitor

Answer 1

Repaglinide (Prandin) belongs to the meglitinides option (C) class of oral antihyperglycemic drugs.

Step-by-step explanation:

Repaglinide (Prandin) belongs to the Meglitinides option (C) class of oral antihyperglycemic drugs. Meglitinides work by stimulating the beta cells of the pancreas to secrete insulin. They have a shorter duration of action compared to other antihyperglycemic drugs.

In the case given, Javier is taking repaglinide along with other medications to manage his type 2 diabetes. However, his poor glycemic control, as evidenced by his elevated A1C and finger stick test result, indicates that his current treatment plan may not be effective. It is important for him to see his doctor and make adjustments to his medications and lifestyle to better manage his diabetes.