Final answer:
The major advantage of repaglinide (Prandin) over other oral antihyperglycemic drugs is that it is specifically effective at lowering postprandial hyperglycemia due to its rapid onset and short duration of action.
Step-by-step explanation:
Javier, a 45-year-old surgical technologist with poorly controlled type 2 diabetes mellitus, has added insulin to his drug regimen due to his glycemic control issues. Among his medications is repaglinide (Prandin) which offers a particular benefit over other oral antihyperglycemic drugs.
The major advantage of repaglinide over other oral antihyperglycemic drugs is that it is effective at lowering postprandial hyperglycemia. Unlike sulfonylureas repaglinide has a rapid onset and a short duration of action which allows it to address blood glucose spikes that occur after meals thereby limiting the risk of prolonged hypoglycemia.