Final answer:
The primary consideration when determining the schedule of medication administration is the specific characteristics of the medications, such as half-life, dose-dependence, and time-dependence.
Step-by-step explanation:
The nurse should recognize that the specific characteristics of the medications are of primary consideration when determining the schedule of administration. This includes factors such as the drug's half-life, which can vary between drugs, and whether the drug is dose-dependent or time-dependent. For example, some drugs have a short half-life and need to be administered multiple times a day, while others have a longer half-life and can be given once a day. Additionally, dose-dependent drugs may need to be administered in large doses for a short time, while time-dependent drugs are more effective when lower levels are maintained over a longer period.