Question

A patient is prescribed temozolomide as a treatment for a brain tumor. Which factors should the nurse evaluate prior to administering the medication? Select all that apply.

a) Temozolomide causes photosensitivity.
b) Temozolomide causes myelosuppression.
c) Temozolomide can cross the blood-brain barrier.
d) Temozolomide can convert to an agent that directly interferes with tumor growth.
e) Temozolomide interacts with other drugs usually taken by brain tumor patients.

Answer 1

Prior to administering temozolomide to a patient with a brain tumor, the nurse should evaluate photosensitivity, myelosuppression, blood-brain barrier penetration, tumor growth interference, and drug interactions.

Step-by-step explanation:

Prior to administering temozolomide to a patient with a brain tumor, the nurse should evaluate several factors:

1. Photosensitivity: Temozolomide can cause photosensitivity, so it is important to assess the patient's sensitivity to sunlight and provide appropriate measures to protect the skin from sun exposure.
2. Myelosuppression: Temozolomide can cause myelosuppression, which is a decrease in the production of blood cells. The nurse should assess the patient's blood cell counts and monitor for signs of infection, anemia, and bleeding.
3. Blood-brain barrier penetration: Temozolomide can cross the blood-brain barrier, allowing it to reach the brain tumor and exert its therapeutic effect. This is an important factor to consider for the drug's effectiveness.
4. Tumor growth interference: Temozolomide can convert to an agent that directly interferes with tumor growth. The nurse should evaluate the patient's response to previous treatments and assess the tumor size and progression.
5. Drug interactions: Temozolomide may interact with other drugs commonly taken by brain tumor patients. The nurse should review the patient's medication list and assess for potential drug interactions that could affect the safety and efficacy of temozolomide.