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Focal Demyelination of the Pons in an alcoholic, dysarthria, dysphagia, dysphonia, and quadreparesis, as well as "locked in syndrome", what's going on?

User Rvf
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1 Answer

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Final answer:

The patient exhibits symptoms of central pontine myelinolysis, a condition common in alcoholics, which can lead to 'locked-in syndrome.' Unlike Amyotrophic lateral sclerosis (ALS), which causes motor neuron degeneration, CPM directly affects the myelin sheath of the brainstem and can progress more acutely.

Step-by-step explanation:

The description provided suggests that the individual is experiencing central pontine myelinolysis (CPM), often related to rapid changes in sodium levels, which can occur in the context of alcoholism. This condition affects the brainstem, particularly the pons, leading to demyelination or damage to the myelin sheath of nerve cells.

Symptoms such as dysarthria (difficulty speaking), dysphagia (difficulty swallowing), dysphonia (voice disorders), and quadriparesis (weakness of all four limbs) align with CPM, and can progress to “locked-in syndrome”, where a person is fully aware but cannot move or communicate due to complete paralysis of nearly all voluntary muscles in the body except for the eyes. Comparatively, Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease that affects motor neurons, leading to muscle weakness, impaired movement, and eventual paralysis. While the initial presentation may be similar, ALS typically does not result in locked-in syndrome as CPM does.

User FuzzyBSc
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