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How do Alpha agonists decrease SA node conduction velocity?

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Final answer:

Alpha agonists decrease SA node conduction velocity by inhibiting sympathetic stimulation and activating alpha-1 adrenergic receptors.

Step-by-step explanation:

Alpha agonists decrease SA node conduction velocity by inhibiting sympathetic stimulation and activating alpha-1 adrenergic receptors. Sympathetic stimulation releases norepinephrine (NE), which binds to the beta-1 receptors in the SA node, increasing heart rate. Alpha agonists, on the other hand, bind to the alpha-1 adrenergic receptors and cause vasoconstriction, reducing sympathetic stimulation. This results in decreased heart rate and conduction velocity at the SA node.

User Jerad Rose
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