Final answer:
Prednisone and NSAIDs provide rapid relief from RA symptoms due to their anti-inflammatory effects, while methotrexate is used for long-term management of the disease.
Step-by-step explanation:
When considering rapid relief of Rheumatoid Arthritis (RA), both methotrexate and prednisone/NSAIDs are potential treatment options, but they serve different roles in the management of the disease. Prednisone is a corticosteroid often used for its quick anti-inflammatory effects to provide rapid relief of RA symptoms. Nonsteroidal anti-inflammatory drugs (NSAIDs), such as aspirin, are also used to reduce inflammation and control pain. In contrast, methotrexate is a disease-modifying antirheumatic drug (DMARD) that is used to reduce the disease's activity and slow down joint damage over a longer term, and it does not provide immediate symptom relief.