Final answer:
IgE-independent drug reactions can occur through non-IgE pathways, such as direct activation of mast cells, and certain drugs like NSAIDs and antibiotics can trigger mast cell degranulation without the involvement of IgE antibodies.
Step-by-step explanation:
While most allergic drug reactions are IgE-dependent and involve mast cell degranulation, there are drugs that can cause IgE-independent reactions. These reactions can occur through non-IgE pathways, such as direct activation of mast cells or other immune cells. One example is non-steroidal anti-inflammatory drugs (NSAIDs) like aspirin and ibuprofen, which can trigger mast cell degranulation without the involvement of IgE antibodies. Another example is certain antibiotics, such as vancomycin and ciprofloxacin, which can directly activate mast cells without IgE involvement.