Final answer:
Topical corticosteroids may have side effects such as skin thinning, hormonal imbalance, and a suppressed immune response. Prolonged use can lead to systemic effects and severe complications like impaired heart function and organ damage, making careful and proper usage essential.
Step-by-step explanation:
Topical corticosteroids, like hydrocortisone, can lead to a variety of side effects. Some common side effects include skin thinning, skin atrophy, stretch marks, and contact dermatitis; these often depend on the potency of the cream, the duration of use, and the area of application. Less frequently, they may cause systemic effects such as hormonal imbalance, hyperglycemia, and suppression of the body's immune response if absorbed at high levels, especially when used over extensive areas of the body or under occlusive dressings.
Prolonged use can also result in features of Cushing's syndrome, adrenal suppression, or exacerbation of the ailment it is treating. Moreover, there are reports of severe side effects such as impaired heart function, testicular atrophy, and prostate enlargement, highlighting the need for caution and appropriate use.