Final answer:
Severe PUD is typically treated with a combination of antibiotics and acid-reducing medications, with recommended therapy protocols including omeprazole, amoxicillin, and clarithromycin, among others. Antacids can provide symptom relief, and in cases of complication like perforation, surgery may be necessary.
Step-by-step explanation:
The treatment for severe Peptic Ulcer Disease (PUD) often requires a combination of medications to eradicate H. pylori, the bacteria commonly responsible for ulcer formation, and to reduce stomach acid. The US Food and Drug Administration recommends using triple therapy protocols, among which are:
- 10 days of omeprazole, amoxicillin, and clarithromycin (OAC).
- 14 days of bismuth subsalicylate, metronidazole, and tetracycline (BMT).
- 10 or 14 days of lansoprazole, amoxicillin, and clarithromycin (LAC).
Medications such as omeprazole, bismuth subsalicylate, and lansoprazole help decrease stomach acid as H. pylori thrives in acidic environments. In addition, antacids may relieve symptoms like "burning" pain and indigestion. If the PUD is complications such as a perforation, emergency surgery may be required.