Final answer:
NSAIDs cause gastric epithelial cell damage by inhibiting the production of prostaglandins, which protect the stomach lining and promote mucus production.
Step-by-step explanation:
NSAIDs, or non-steroidal anti-inflammatory drugs, cause gastric epithelial cell damage by inhibiting the production of prostaglandins in the stomach. Prostaglandins are responsible for protecting the gastric mucosa and promoting mucus production, which acts as a barrier between the stomach tissue and acid.
When NSAIDs suppress prostaglandin synthesis, the gastric mucosal barrier breaks down, leaving the epithelial cells vulnerable to damage from gastric acid. This can lead to inflammation, gastritis, and the development of ulcers.
An example of an NSAID commonly used is aspirin. Prolonged or excessive use of NSAIDs can increase the risk of gastrointestinal damage, including damage to gastric epithelial cells.