Final answer:
Neurological complications, especially seizures, are the most common cause of death in patients with tuberous sclerosis, due to the brain tumors associated with the disease.
Step-by-step explanation:
In patients with tuberous sclerosis, the most common cause of death (mcc) is related to neurological complications. Tuberous sclerosis can lead to the formation of benign tumors called hamartomas in various organs, including the brain. When these tumors affect the brain, they can cause seizures, which are a significant cause of morbidity and can be life-threatening. In severe cases, the growth of these tumors can lead to increased intracranial pressure, brain damage, or obstructive hydrocephalus, all of which can be fatal.
Additionally, renal complications due to angiomyolipomas in the kidneys and cardiac rhabdomyomas can also contribute to mortality in these patients. Therefore, while tuberous sclerosis presents with a variety of symptoms across different organ systems, it is the neurological complications, particularly seizures, that most often lead to mortality.