Final answer:
In the Renin-Angiotensin-Aldosterone System, renin converts angiotensinogen to angiotensin I, which is then transformed into angiotensin II by the angiotensin-converting enzyme (ACE), influencing blood pressure and fluid balance.
Step-by-step explanation:
The Renin-Angiotensin-Aldosterone System (RAAS) plays a crucial role in the regulation of blood pressure and fluid balance in the body. To fill in the blanks: In RAAS, renin converts angiotensinogen to ANG1 which is then converted into ANG2 via ACE (angiotensin-converting enzyme). Renin, which is secreted by the juxtaglomerular cells in the kidneys, acts on angiotensinogen, a protein produced by the liver. This interaction produces angiotensin I (ANG1), which is then converted into the physiologically active angiotensin II (ANG2) by ACE, an enzyme found primarily in the lungs. Angiotensin II has multiple effects, including vasoconstriction and stimulating the release of aldosterone from the adrenal glands and antidiuretic hormone (ADH) from the posterior pituitary, which both work to increase blood pressure and fluid retention.