Final answer:
The main side effect of chronic NSAID use is an increased risk of gastrointestinal ulcers and bleeding, as well as kidney damage and an increased risk of heart attack or stroke.
Step-by-step explanation:
The main side effect of chronic use of nonsteroidal anti-inflammatory drugs (NSAIDs) is an increased risk of gastrointestinal ulcers and bleeding. This risk is particularly high in individuals who are over 60 years of age, take prescription blood thinners, steroids, have a history of stomach bleeding or ulcers, or have underlying bleeding disorders. Furthermore, chronic use of NSAIDs can also lead to kidney damage, especially in individuals with pre-existing kidney disease, heart disease, or high blood pressure, and those taking diuretics. While NSAIDs, which include medications such as aspirin, ibuprofen, and naproxen, are designed to reduce pain, inflammation, and fever, and prevent blood clots, their use must be balanced with the potential side effects. Over time, NSAIDs can cause not only gastrointestinal issues and kidney problems but also an increased risk of heart attack or stroke due to their effect on prostaglandin synthesis. NSAIDs are different from acetaminophen, which has a lower risk of GI side effects but can cause severe liver damage in the event of an overdose.