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_________________are antimicrobial substances that are applied to living tissue/skin to reduce the possibility of infection, sepsis, or putrefaction.

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Antiseptics are vital antimicrobial substances used on living tissues to prevent infection without causing harm to the tissue itself. They must be selectively effective against microbes and not toxic to humans, as demonstrated by products like hydrogen peroxide and isopropyl alcohol. The historical use of antimicrobials dates back to ancient civilizations, and now, antiseptics form a crucial part of infection control in modern medicine.

Step-by-step explanation:

Antiseptics are antimicrobial substances that are specifically formulated to be applied to living tissue or skin to reduce the likelihood of infection, sepsis, or putrefaction. Unlike harsh disinfectants, which are utilized on inanimate objects, antiseptics must be gentle enough to avoid damaging live tissue while remaining effective in combating microbial growth. Examples of common antiseptics include hydrogen peroxide and isopropyl alcohol. These substances undergo a process known as antisepsis, a crucial protocol in healthcare and first aid situations to ensure the cleanliness and safety of living tissues.

The properties of successful antiseptics involve selective activity against harmful microorganisms, the ability to deeply penetrate tissue, and ensuring they do not cause tissue damage. When considering antiseptics, some are labeled as '-static,' meaning they halt the growth of microbes rather than killing them outright, which can be a preferable option for reducing toxicity when applied to living beings or sanitized products like toys and food preparation tools. Moreover, understanding the extent of an antiseptic's effectiveness is often compared against standard treatments like phenol, once used by Joseph Lister, through methods like broth dilution or disk diffusion assay, assessing the zone of inhibition's size.

Additionally, while the use of antiseptics is synonymous with modern medicine, historical evidence shows that ancient cultures also recognized the importance of antimicrobial agents, as seen with antibacterial compounds such as tetracycline being used as early as 350 AD in Nubia. Today, antiseptics continue to be a vital component of healthcare, preventing infections during surgeries, in wound care, and in general hygiene practices to control the spread of pathogens.

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