Final answer:
The medication that requires a patient package insert is estrogen. These inserts are necessary for high-risk medications to provide patients with detailed information regarding the drug's use, dosage, side effects, and associated risks.
Step-by-step explanation:
The medication that must be dispensed with a patient package insert is estrogen. Medications like estrogen, that are a part of hormone replacement therapy, require these inserts because they carry significant risks, including an increased risk of serious conditions like blood clots, breast cancer, and heart disease. The Food and Drug Administration (FDA) mandates that these inserts provide patients with accessible, comprehensive information regarding the uses, dosage, potential side effects, and risks associated with the medication.
Aspirin, ibuprofen, and nitroglycerin are commonly sold over the counter and typically do not require a patient package insert when dispensed in their nonprescription forms. Although they are commonly used to manage pain and cardiovascular conditions, they do not carry the same level of risk that necessitates such detailed patient education inherent to estrogen.