Final answer:
You can typically make a U-turn from the leftmost lane of your direction of travel, ensuring the maneuver is allowed and can be completed safely.
Step-by-step explanation:
You are allowed to make a U-turn from the lane that is furthest to the left in your direction of travel, provided there are no signs or road markings prohibiting U-turns. This usually means the lane next to the median in divided roads, or the leftmost lane on undivided roads.
It's important to always follow the specific road rules of your jurisdiction, as they can vary between different locations. However, in any case, safety is paramount—you must ensure the maneuver can be completed safely without interfering with oncoming traffic or pedestrians.