Final answer:
The adverse effects of first-generation antihistamines include sedation, dry mouth, and urinary retention. Pruritus, or itching, is not one of the usual side effects. First-generation antihistamines primarily block histamine receptors in the body to alleviate allergy symptoms.
Step-by-step explanation:
The adverse effects of first-generation antihistamines include sedation, dry mouth, and urinary retention. However, pruritus, which refers to itching, is not one of the usual side effects of first-generation antihistamines. These medications primarily work by blocking histamine receptors in the body, which helps alleviate symptoms of allergies such as sneezing and nasal congestion.