Final answer:
Necrosis is always pathological as it is an unregulated process leading to cell death, typically resulting from harmful factors and is associated with inflammation, contrasting with the regulated nature of apoptosis.
Step-by-step explanation:
The statement that necrosis is ALWAYS pathological is true. Necrosis is a form of cell injury which results in the premature death of cells in living tissue by autolysis. Unlike apoptosis, which is a form of programmed cell death that occurs in a regulated and controlled manner, necrosis is typically associated with inflammation and results from factors such as infection, toxins, or trauma that cause damage to cells. As it is unregulated, necrosis usually leads to detrimental effects on the organism and thus is considered pathological. The presence of necrotic cells identified by their orange-fluorescence, loss of plasma membrane integrity, and absence of apoptotic bodies, as well as the cytoplasmic swelling indicated by an asterisk, contrasts with the controlled nuclear changes characteristic of apoptosis, which are marked by the presence of white arrows in microscopic images.