Check the picture below.
so the line OR has a slope of 5/4, what's the slope of QR anyway?
keeping in mind that perpendicular lines have negative reciprocal slopes, hmmm what's the slope of a line perpendicular to OR?
well, let's recall that the point of tangency in a circle is always at a right-angle, so if OR ⟂ QR then QR's slope should be -4/5, which it is, that means they're indeed perpendicular, and the product for two perpendicular slopes is -1, like in this case.