Final answer:
Patients with neuromuscular disorders like Myasthenia Gravis and those with burn injuries may be resistant to nondepolarizing NMBAs, requiring higher doses for surgical anesthesia.
Step-by-step explanation:
Individuals with certain neuromuscular disorders can have resistance to nondepolarizing Neuromuscular Blocking Agents (NMBAs). For example, patients with Myasthenia Gravis exhibit resistance to these medications due to a chronic deficiency of functional acetylcholine receptors at the neuromuscular junction. Similarly, individuals with Burn injuries may also develop resistance to nondepolarizing NMBAs because of receptor upregulation. In these cases, higher doses of the medication may be necessary to achieve the desired paralysis during anesthesia. It is vital for practitioners to consider these conditions as well as the specific pharmacokinetic and pharmacodynamic properties of the chosen NMBA when planning anesthesia for surgery.