Final answer:
The fall of Constantinople led to its renaming as Istanbul and it became the Ottoman Empire's capital, with its strategic location at the Europe-Asia crossroads enhancing its significance.
Step-by-step explanation:
After the fall of Constantinople in 1453 to the Ottomans, led by Sultan Mehmed II, the city was renamed Istanbul and it became the new capital of the Ottoman Empire. The location of the city is highly significant because it is situated at the crossroads of Europe and Asia, controlling the Bosphorus and Dardanelles straits that connect the Mediterranean Sea with the Black Sea. This strategic position made it the gateway between the two continents and a hub for trade and military campaigns. The Siege of Constantinople and its subsequent fall marked a pivotal change in history, influencing the region politically, culturally, and economically, and also had a far-reaching impact that contributed to the advent of the Renaissance in Western Europe.