Final answer:
George's statement reflects his feelings of frustration, resentment, and exasperation towards Lennie, as George cares deeply for Lennie but is exasperated by his actions.
Step-by-step explanation:
George's statement, "...you're a lot of trouble," expresses his feelings of frustration, resentment, and exasperation towards Lennie. Option c) is the best choice as George cares deeply for Lennie but is exasperated by his actions. Throughout the story, George continuously looks out for Lennie's well-being, but Lennie's forgetfulness and dependence on George often put them both in challenging situations.