Final answer:
Lead V1 in a 12-lead ECG should be placed in the fourth intercostal space at the right sternal border.
Step-by-step explanation:
When applying the precordial leads for a 12-lead ECG, lead V1 should be positioned at the fourth intercostal space at the right sternal border. To place lead V1 accurately, locate the sternum, which is the elongated bony structure at the center of the anterior thoracic cage. The fourth intercostal space can be found by counting down from the jugular notch at the top of the manubrium (the superior portion of the sternum) to the fourth gap between the ribs. Place lead V1 on the right side of the sternum, within this fourth intercostal space.