Final answer:
The subject of the question relates to the historical conflicts and tensions within Pennsylvania during its early colonial period, including border disputes, religious communities, relations with Native American tribes, and regional uprisings against taxes.
Step-by-step explanation:
The question involves the complex historical relations between Protestant settlers, Native Americans, and colonial leaders in Pennsylvania during the early growth of what would become the United States. Initially, Pennsylvania was founded by William Penn through a charter granted by King Charles II, which led to border conflict with Maryland over the ill-defined borders, a situation not resolved until the Mason-Dixon Line survey in the 1760s.
Religious tensions were also notable, with the founding of pietistic societies such as the Ephrata Cloister which became an early example of communal experiments in America. Furthermore, the underlying tension between Protestants and Catholics in Maryland persisted through the years, exacerbating regional conflicts.
Meanwhile, Pennsylvania's peace with Native American tribes became threatened as the rapid European expansion demanded more land, leading to broken treaties and increased hostilities. The refugees served as a buffer against French forces during the war for empire but were eventually pushed out by settlers' land hunger.
Additionally, the subject touches upon Fries's Rebellion as another example of regional dissent, this time against a federal tax, which hinted at the brewing sentiments that would later explode during the American Revolution.