Final answer:
The Thames River is the waterway that flows through England and connects London with the North Sea.
Step-by-step explanation:
The river that flows through England and connects London with the North Sea is the Thames River. London is situated along the banks of the Thames, which has played a vital role in the city's history, serving as a main waterway for trade, transport, and even waste disposal. Despite periods of severe pollution, such as during the 'Great Stink' of 1858 when the Thames was heavily contaminated with sewage, the river remains an iconic part of London's geography and an important route to the sea.