Final answer:
The Seine River is the waterway that carries the majority of France's inland traffic and leads to the English Channel.
Step-by-step explanation:
The river that carries most of France's inland waterway traffic and empties in the English Channel is the Seine River. The Seine is not only significant for its commercial transport but also because it passes through Paris, the heart of French nationhood, where historical landmarks like the Notre Dame Cathedral stand on the Île de la Cité. This river is a quintessential part of French identity and infrastructure, linking key economic and cultural areas within the country.