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Signal transduction with the alpha-1 receptor?

What are some other receptors that behave this way?
a) Increases cAMP production; Beta-2 receptors
b) Increases IP3/DAG production; M1 receptors
c) Inhibits adenylate cyclase; Beta-1 receptors
d) Inhibits guanylate cyclase; Alpha-2 receptors

User Seymour
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1 Answer

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Final answer:

Signal transduction involves a series of molecular events that are triggered by an initial stimulus, leading to a cellular response. The alpha-1 receptor activates phospholipase C which increases IP3/DAG production, similar to M1 receptors. Beta-2 receptors increase cAMP production, while alpha-2 receptors inhibit adenylate cyclase, unlike beta-1 receptors which promote it.

Step-by-step explanation:

The student is asking about signal transduction involving the alpha-1 receptor and its comparison to other receptors. Signal transduction is the process by which a chemical or physical signal is transmitted through a cell as a series of molecular events, most commonly involving an initial stimulus triggering the production of a secondary messenger molecule. G-protein-coupled receptors (GPCRs) like alpha-1 trigger different cellular responses upon activation by extracellular ligands.

The alpha-1 receptor typically activates phospholipase C, leading to the production of inositol trisphosphate (IP3) and diacylglycerol (DAG), which further leads to the release of calcium and other cellular responses. Beta-2 receptors, on the other hand, lead to increases in cAMP production when stimulated, which involves the activation of protein kinase A (PKA) and the initiation of various cellular activities. The M1 receptors are similar to alpha-1 in that they also increase IP3/DAG production. Alpha-2 receptors inhibit adenylate cyclase, thereby decreasing cAMP levels, and unlike the beta-1 receptors which generally increase cAMP production, alpha-2 receptors are unique in that they inhibit guanylate cyclase.

User Santiago Palladino
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