Question

: The LA molecule is constructed of what 3 key components?

a) A lipophilic group, an intermediate chain, and a hydrophilic group
b) An aromatic ring, an ester linkage, and a hydroxyl group
c) A tertiary amine, an alkyl group, and a quaternary ammonium ion
d) An ether linkage, a carboxylic acid group, and a halogen atom

Answer 1

The LA molecule is constructed of three key components: a lipophilic group, an intermediate chain, and a hydrophilic group. The example of Procaine illustrates these parts, which include an aromatic acid, an alcohol, and a tertiary amino group.

Step-by-step explanation:

The LA molecule, often referred to in the context of local anesthetics, is constructed of three key components. The correct option that describes these components is:

• A lipophilic group
• An intermediate chain
• A hydrophilic group

For instance, in the case of Procaine, these parts are the aromatic acid (para-aminobenzoic), the alcohol (ethanol), and the tertiary amino group (diethylamino). The ester link between these domains is crucial as it allows for hydrolysis during metabolic degradation, affecting the compound's anesthetic potency and toxicity. Furthermore, the length of the alcohol group can influence both the potency and toxicity of the anesthetic.

Therefore, the correct answer to the question 'The LA molecule is constructed of what 3 key components?' is option a: A lipophilic group, an intermediate chain, and a hydrophilic group.