Final answer:
The prolonged application of a wet burn dressing can increase the risk of hypothermia due to the body's heat being drawn away by the moist dressing, in addition to the significant risk of infection on the damaged skin.
Step-by-step explanation:
The risk of prolonged application of a wet burn dressing to a significant burn injury is hypothermia. When a burn occurs, the skin is damaged, leading to cell death and the potential for significant fluid loss. This can cause dehydration, electrolyte imbalance, and circulatory failure, which can become fatal if not treated promptly with intravenous fluids and nutrients. Moreover, application of a wet dressing for an extended period may lower body temperature as moisture is conducive to heat loss, increasing the risk of hypothermia. It is essential to observe for signs of infection, as burned skin is highly susceptible to infection due to the loss of protection by the intact layers of skin.