Final answer:
To decrease the incidence of psychomimetic reactions associated with ketamine, lower doses, premedication with benzodiazepines, combining with other anesthetics, controlled settings, and the potential of pharmacogenomics can be employed.
Step-by-step explanation:
To decrease the incidence of psychomimetic reactions associated with ketamine, a provider can employ several strategies. Firstly, utilizing lower doses of ketamine can reduce the likelihood of these reactions. Secondly, premedication with benzodiazepines, such as midazolam, can have an ameliorating effect on the emergence phenomena frequently seen with ketamine anesthesia. Thirdly, combining ketamine with other forms of anesthetics, such as propofol or barbiturates, can diminish the psychomimetic effects as these drugs can balance the dissociative effects of ketamine with their more sedative properties.
Administering ketamine under controlled settings with the assistance of trained personnel can also improve patient outcomes and reduce the incidence of psychomimetic reactions. It is pertinent to observe the patient closely for any signs of distress or unusual behavior and to provide supportive measures such as a calm, quiet environment, and verbal reassurance. Furthermore, the emerging field of pharmacogenomics holds promise for identifying patients who might be more prone to adverse reactions to drugs like ketamine and customizing treatment to mitigate these risks.