Final answer:
Erythromycin and Azithromycin are macrolides, with the former being susceptible to bacteria's resistence developing and the latter offering a broader activity spectrum, fewer side effects, and convenient dosing. Nursing considerations include monitoring for adverse effects, ensuring therapy completion, and assessing for drug interactions.
Step-by-step explanation:
Nursing Considerations for Macrolides: Erythromycin and Azithromycin
Erythromycin and Azithromycin are both macrolides, a class of antibiotics known for their role in inhibiting protein synthesis in bacteria by binding to the 50S ribosomal subunits. Erythromycin, isolated from Streptomyces erythreus, may act bacteriostatic or bactericidal depending on the drug concentration and microorganism. Azithromycin, a semisynthetic macrolide, offers a broader spectrum of activity, fewer side effects, and a longer half-life compared to Erythromycin, allowing for once-daily dosing. Nursing considerations for these antibiotics include monitoring for signs of an allergic reaction, ensuring the completion of the entire course of therapy to prevent resistance, and assessing for potential drug interactions.
Erythromycin is indicated for the treatment of various bacterial infections such as respiratory tract infections and skin infections. During administration, it is essential to monitor for common side effects such as gastrointestinal upset and to advise patients to report severe reactions like jaundice, which may indicate hepatotoxicity. Likewise, Azithromycin is susceptible to inducing gastrointestinal side effects and nurses should counsel patients accordingly. Lastly, it is crucial to assess for contraindications, such as preexisting liver disease, and for interactions with other medications the patient may be taking.