Final answer:
The client's statement that indicates the need for further explanation is that combination chemotherapy is used to destroy cancer cells and treat side effects simultaneously.
Step-by-step explanation:
The client's statement that indicates the need for further explanation is: 2. "Combination chemotherapy is used to destroy cancer cells and treat side effects simultaneously."
This statement is incorrect because combination chemotherapy is used to destroy cancer cells, but it does not specifically target and treat side effects. Side effects of chemotherapy are managed through various supportive measures, such as medications to alleviate nausea and pain, and lifestyle modifications.
On the other hand, statements 1, 3, and 4 are accurate. Combination chemotherapy is indeed used to interrupt cell growth at different points, decrease resistance, and minimize toxicity by using lower doses of multiple drugs instead of high doses of a single agent.