Question

Codeine poor metabolizers = __________ pain relief

Answer 1

Codeine-poor metabolizers have diminished pain relief because their bodies are less effective at converting codeine into morphine due to a genetic variation affecting the CYP2D6 enzyme. The option (C) is correct.

Step-by-step explanation:

Codeine-poor metabolizers experience diminished pain relief. Codeine is metabolized in the liver by an enzyme called CYP2D6 to morphine, which is responsible for its pain-relieving effects.

Individuals who are poor metabolizers of codeine have a genetic variation that makes this enzyme less active, resulting in reduced conversion of codeine to morphine, and therefore, they receive less benefit from codeine for pain management. Therefore, option (C) is correct.

This question is not complete, Here I am attaching the complete question:

Codeine-poor metabolizers = __________ pain relief.

A. Enhanced

B. Standard

C. Diminished

D. Accelerated