Final answer:
The largest paranasal sinuses are the maxillary sinuses, located in the maxillary bones below the orbits. They are significant for their tendency to be involved in sinus infections due to drainage challenges.
Step-by-step explanation:
The largest of the paranasal sinuses are the maxillary sinuses. These sinuses are paired and located within the right and left maxillary bones, just below the orbits (eye sockets). The maxillary sinuses are particularly significant because they are the sinuses most commonly involved during sinus infections. Their position makes them difficult to drain, as their connection to the nasal cavity is high on their medial wall. The paranasal sinuses, including the frontal sinus, sphenoid sinus, and ethmoid air cells, each named for their associated bone, serve essential functions such as reducing bone mass to lighten the skull, warming and humidifying incoming air, and adding resonance to the voice.