Final answer:
The most optimal fluid-replacement option for Maggie's significant blood loss is whole blood, as it contains all the necessary components for effective fluid replacement.
Step-by-step explanation:
When considering Maggie's significant blood loss, the most optimal fluid-replacement option would be whole blood (Option A). Whole blood is the normal consistency of blood in the body and contains all the components needed for effective fluid replacement, including red blood cells, white blood cells, platelets, and plasma.