Final answer:
To evaluate the effectiveness of a PPI, the nurse should assess symptom reduction, use objective measures such as endoscopic findings, pH monitoring, and laboratory tests to check gastric acid production.
Step-by-step explanation:
After administering a proton pump inhibitor (PPI), the nurse should evaluate its effectiveness by assessing the reduction of symptoms such as heartburn, acid reflux, and indigestion. Additionally, objective measures like improvement in endoscopic findings or pH monitoring of the esophagus may be used where applicable. In some cases, laboratory tests to check for decreased gastric acid production can also be helpful. The nurse should monitor for signs of healing of gastroesophageal reflux disease (GERD) or ulcers if those were the indications for the PPI therapy.