Final answer:
To improve glycemic control in adults with Type 2 Diabetes, the eGFR cutoff is <60 mL/min/1.73 m² for staging chronic kidney disease, which affects drug choice and dosage. GFR below 30 mL/min/1.73 m² requires careful consideration of medications. GFR is typically estimated via creatinine levels.
Step-by-step explanation:
Based on indication and kidney function, to improve glycemic control in adults with Type 2 Diabetes, the eGFR cutoff is dependent on the stage of Chronic Kidney Disease (CKD) they are classified in.
Individuals with a Glomerular filtration rate (GFR) of <60 mL/min/1.73 m² for 3 months are considered to have chronic kidney disease.
This level of reduction in kidney function indicates a loss of at least half of the normal kidney function, which may lead to complications.
When managing diabetes in the context of kidney disease, the avoidance of drugs that may further impair kidney function or that require dosage adjustment based on kidney function is critical.
Therefore, the eGFR is used not only to stage CKD but also to tailor diabetic therapy appropriately. A key point to remember is that with a GFR below 30 mL/min/1.73 m², many drugs used for glycemic control in diabetes need to be used with caution or are contraindicated.
Determination of the GFR helps in assessing kidney excretory function and in the administration of appropriate drug dosages for drugs primarily excreted by the kidney.
Estimating GFR is typically done by measuring levels of creatinine, a by-product of muscle metabolism.