Final answer:
Irreversible loss of kidney function is called end-stage renal disease. This condition often requires renal replacement therapy, such as dialysis or kidney transplant, to sustain life.
Step-by-step explanation:
Irreversible loss of kidney function is called end-stage renal disease. End-stage renal disease is the final stage of chronic kidney disease, where the kidneys are no longer able to function effectively. This condition often requires renal replacement therapy, such as dialysis or kidney transplant, to sustain life.