Final answer:
The liver, spleen, and bone marrow are the main sites for extravascular destruction of erythrocytes and iron storage in the form of ferritin and hemosiderin. These organs store and recycle iron for new erythrocyte production. Iron is transported by transferrin when needed.
Step-by-step explanation:
The three main sites of extravascular destruction and Iron storage are the liver, spleen, and bone marrow. These organs are responsible for the degradation of old and damaged erythrocytes through the action of macrophages that phagocytize these cells. The iron from hemoglobin within these cells is then stored in these organs predominately in two forms: ferritin and hemosiderin.
In the liver, iron can be stored in significant amounts and is protected against loss by bleeding or other causes. The spleen functions as a site for iron recycling in addition to its role in erythrocyte destruction. Lastly, the bone marrow is where the iron is utilized for the formation of new erythrocytes. When the body requires iron for new blood cell production, it is transported by transferrin from these storage sites to where it is needed.