Final answer:
Stevens Johnson Syndrome and Toxic Epidermal Necrolysis are severe skin conditions that can cause serious body-wide complications, including infections like cellulitis and necrotizing fasciitis, fluid imbalance, sepsis, eye problems that may affect vision, and potential scarring and strictures in mucous membranes.
Step-by-step explanation:
Stevens-Johnson Syndrome (SJS) and Toxic Epidermal Necrolysis (TEN) are severe hypersensitivity reactions that primarily affect the skin and mucous membranes. These conditions can lead to significant complications throughout the body due to widespread epidermal necrolysis. SJS/TEN involves the detachment of the epidermis from the dermis, causing blistering and erosion of the skin. These conditions often begin with flu-like symptoms, followed by the rapid onset of a painful rash that spreads and blisters.
Complications of SJS/TEN include infection, as the skin forms a primary barrier against pathogens. When this barrier is disrupted, bacteria can cause infections such as cellulitis or necrotizing fasciitis. Moreover, the loss of skin leads to fluid imbalance and may necessitate intravenous fluid therapy. Another complication is sepsis, which can occur if the infection becomes systemic. Patients may experience eye problems, including severe dry eye or damage that may lead to vision loss. Long-term effects can include scarring, both externally and on mucous membranes, potentially causing complications such as strictures.