Final answer:
Following the second defibrillation shock and continued CPR, the next step is to administer epinephrine per ACLS guidelines, followed by antiarrhythmic drugs if v-fib persists.
Step-by-step explanation:
After the second shock and resumption of chest compressions, the next intervention should be the administration of medication, as indicated in Advanced Cardiac Life Support (ACLS) protocols. The first drug typically given during cardiac arrest is epinephrine, which aids in stimulating the heart and improving blood flow to body tissues during CPR. In the case of persistent ventricular fibrillation (v-fib), antiarrhythmic drugs such as amiodarone or lidocaine may also be administered. It is crucial to follow the established ACLS algorithm, which provides guidance on the use of medications and further defibrillation attempts.