Final answer:
Hydrocortisone and Methylprednisolone are prescribed for significant asthma to reduce inflammation and ease symptoms by mimicking cortisol's immune system downregulation and anti-inflammatory effects.
Step-by-step explanation:
Hydrocortisone and Methylprednisolone are administered to patients with significant asthma because they are synthetic corticosteroids that mirror the action of cortisol in downregulating the immune system and inhibiting the inflammatory response. These drugs are effective in reducing inflammation associated with asthma and other inflammatory or immunologically mediated disorders. By preventing or reducing the inflammatory response, these corticosteroids help to alleviate the symptoms of asthma such as wheezing, coughing, and shortness of breath.
Corticosteroids like Hydrocortisone and Methylprednisolone work by reducing the secretion of histamine, which in turn decreases the body's inflammatory response. This is especially important in the lungs where inflammation can cause airways to narrow, leading to asthma symptoms. They are often used as part of a longer-term treatment regimen for those with more severe asthma and are effective in managing the condition by allowing the lung lesions to heal and reducing the frequency of asthma attacks.