Final answer:
Fibrinolytic therapy for ischemic stroke, often using tissue plasminogen activator, requires blood pressure control, typically below 140/90 mmHg with diastolic pressure not going below 60 mmHg, to avoid complications such as hemorrhage.
Step-by-step explanation:
The question pertains to the criteria for withholding fibrinolytic therapy in patients with acute ischemic stroke. Fibrinolytic therapy involves medications such as tissue plasminogen activator (tPA) that dissolve blood clots and can prevent permanent brain damage if administered within a critical time window after a stroke. According to guidelines, the diastolic blood pressure should not be excessively high before administering these medications, specifically, it should typically be reduced to less than 140/90 mmHg, with a lower limit generally suggested around 60 mmHg. Optimal blood pressure management is critical before giving fibrinolytics to avoid potential complications such as hemorrhage. Beta blockers are often recommended to manage high blood pressure in this clinical setting. It is important to note that time is a crucial factor in treating ischemic strokes, and thrombolytic agents are most effective within the first 3 hours of the onset of stroke symptoms.