Final answer:
Nortriptyline is the second-line pharmacotherapy for smoking abstinence.
Step-by-step explanation:
The second-line pharmacotherapy for smoking abstinence is Nortriptyline. While nicotine replacement therapies like gum and patches are commonly used as first-line treatments, nortriptyline is typically reserved as a second-line option for individuals who have not responded well to other treatments or who have contraindications to nicotine replacement therapy. Nortriptyline is an antidepressant that can help reduce withdrawal symptoms and cravings associated with quitting smoking.